Viral etiology of human cancer: a historical perspective.

The relationship between Human Papillomavirus and Epstein-Barr virus infections with breast cancer of Iranian patients

Background: Breast cancer is the malignancy in humans and other mammals. Several risk factors are involved in their appearance such as higher hormone levels and obesity. Identification of a mouse mammary tumor virus supports a viral etiology for breast tumors in animals. Viruses have been implicated in the development of various cancers, but viral induction for formation breast cancer is contro...

Description of the human races: A historical perspective

HLA-KIR Interactions and Immunity to Viral Infections

Host genetic factors play a central role in determining the clinical phenotype of human diseases. Association between two polymorphic loci in human genome, human leukocyte antigen (HLA) and killer cell immunoglobulin-like receptors (KIRs), and genetically complex infectious disease, particularly those of viral etiology, have been historically elusive. Hence, defining the influence of genetic di...

Reproductive and hormonal risk factors of breast cancer: a historical perspective

The complexity of breast cancer etiology has puzzled scientists for more than 300 years. In this brief review, we emphasize the importance of reproductive and hormonal factors in relation to the risk of breast cancer. By following the historical course of how various risk factors have been determined, this study attempts to illustrate the origin of hypotheses, their subsequent rejection, and de...

Technology and Urban Form: A Philosophical and Historical Perspective

Urban form has undergone tremendous changes throughout history. These changes have stemmed from various causes. Technology has been one of the most influential forces in changing the face of cities, leaving different marks on the city form. In fact, technology has gained an increasingly more important and integrative role in bringing changes to the urban form. In addition, recent plethora of de...